Imetelstat (grn163l)--telomerase-based Cancer Therapy

Telomerase And The Search For The End Of cancer
The second telomerase-based gene therapy approach ments the bioavailability of imetelstat/GRN163L, an Telomerase and the search for the end of cancer Author: Simone Mocellin Subject: Trends in Molecular Medicine, 19 (2013) ... Read More

Cancer Puri And Girard - Omicsonline.org
Science & Therapy Puri and Girard, J Cancer Sci Ther 2013, 5.10 http://dx.doi.org/10.4172/1948-5956. 1000e127 Volume 5(10) - 1000e127 Röth A, Harley CB, Baerlocher GM (2010) Imetelstat (GRN163L)--telomerase-based cancer therapy. Recent Results Cancer Res 184: 221-234. ... Read Full Source

Telomerase - Wikipedia, The Free Encyclopedia
Who also suggested the telomere hypothesis of aging and the telomere's connections to cancer. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1984 in Approaches to controlling telomerase and telomeres for cancer therapy include gene Imetelstat (GRN163L) ... Read Article

Targeting Telomerase With The Oligonucleotide GRN163L For ...
Targeting telomerase with the oligonucleotide GRN163L for cancer therapy Sònia Font Oligonucleotides used for cancer therapy are N3' P5' phosphoramidates (DNA analogues). GRN163L (Imetelstat) (GeronTM corporation): most Will tumor cells evolve escape mechanisms to telomerase based ... Document Retrieval

Latest Therapeutic Approaches Based On Cancer Stem Cells
Latest Therapeutic Approaches Based on Cancer Stem Cells telomerase is an important drug target for CSCs. Imetelstat (GRN163L), a targeting Oct4 may have important clinical applications in cancer and CSC therapy. Emerging data indicate that transglutaminase 2 ... Fetch Here

Telomerase Targeted Therapy In Cancer And Cancer Stem Cells
Ment of the various telomerase-based therapeutic approaches, Telomerase Targeted Therapy in Cancer and Cancer Stem Cells Yucheng Xu, PhD, Kaijie He, Imetelstat (GRN163L) is an oligo-nucleotide with the sequence TAGGGTTAGACAA that ... Access Doc

L’arrive´e Des Inhibiteurs De Te´lome´rase Constitue Un ...
Imetelstat (GRN163L) o ¨ telomerase-based cancer therapy. Recent Results. Cancer Res 2010 ; 184 : 221-34. 5. SpanoudakisE,Bazdiara I,Pantelidou D,etal.Dynamicsoftelomere’slength andtelomeraseactivityinPhiladelphiachromosomenegativemyeloproliferative ... View Document

21 - InTech
Develop resistance to telomerase-based therapies than they are to other cancer targets that Imetelstat (GRN163L), a specificinhibitor of the reverse transcriptase activity of telomerase, with metastatic colorectal cancer[21]. ... Document Retrieval

Recent Results In Cancer Research 184 - Springer
3.4.2 Axitinib in Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 3.4.3 Axitinib in Metastatic Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . 38 3.4.4 ... Return Doc

Therapeutic Potential Of A Peptide Targeting BCL-2 Cell ...
Imetelstat (GRN163L)—telomerase-based cancer therapy. Recent Results Cancer Res. 2010;184:221–234. 11. Begus-Nahrmann Y, et al. Transient telomere dysfunction ... Doc Retrieval

Imetelstat (GRN163L) - Telomerase-Based 16 Cancer Therapy
16 Imetelstat (GRN163L) -Telomerase-Based Cancer Therapy 225 chemistry, imetelstat has very good cellular and tissue penetration even with lower concentra- ... Read Here

Contents
16 Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy. . . . . . . . . . . 221 Alexander Röth, Calvin B. Harley, and Gabriela M. Baerlocher 16.4 Structure of Imetelstat and Mechanism of Action . . . . . . . . . . . . . 224. Contents xi ... Fetch Document

Small Molecules In Oncology - Beck-shop.de
Small Molecules in Oncology von Uwe M. Martens 1st Edition. Small Molecules in Oncology – Martens schnell und portofrei erhältlich bei beck-shop.de DIE FACHBUCHHANDLUNG and Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 ... Fetch Doc

Tumor And Stem Cell Biology Cancer Research The Telomerase ...
In this study, we investigated the effects of imetelstat (GRN163L), a potent telomerase Our results suggest that imetelstat-mediated depletion of CSCs may offer an alternative mechanism by which telomerase inhibition may be exploited for cancer therapy. Cancer Res; 70(22); 9494–504. ©2010 ... View Full Source

Geron Corporation - Wikipedia, The Free Encyclopedia
Geron Corporation is a biotechnology company located in Menlo Park, Presently Geron is recruiting patients for six clinical trials using GRN163L, [5] including lung cancer, The company is in the early stages of developing a telomerase based treatment for HIV called TAT0002, ... Read Article