Dna Intercalators In Cancer Therapy

Targeting Biological Systems By Organic Synthesis Methods ...
Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins 2 Cancer Therapy 2.4 DNA Intercalators ..17 2.4.1 Radionuclide-Containing DNA Intercalators ... Read Document

The Hypoxic Cell: A Target For Selective Cancer Therapy ...
The Hypoxic Cell: A Target for Selective Cancer Therapy—Eighteenth Bruce F. Cain Memorial Award Lecture1 J. Martin Brown2 Even for non-DNA intercalators, such as melphalan, there can be a problem in nonhomogeneous distribution from the blood vessel (29). ... Read Here

Cancer Therapy Using Antibiotics
Effects and development of drug resistance in cancer cells. This therapy (often abbreviated to chemo) Cancer Therapy Using Antibiotics Author: Biplob Bhattacharya, Sreya Mukherjee Some act as DNA intercalators or some prevent DNA repair among other mechanisms of actions, they are seen to ... Read Here

Recent Developments In The Chemistry Of Deoxyribonucleic Acid ...
A very good (mini-)review on DNA intercalators in cancer therapy has been recently published [21]. However, the topic is far from being exhausted. Clinical applications are Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, ... Read Content

CANCER - Research
Which can both act as DNA intercalators and Inhibit initiation and promotion of cancer and induce apoptosis Type of cancers breast, renal, prostate, brain, liver and stomach Use for adjuvant therapy to prevent recurrence Advantages: Substantially ... Doc Retrieval

European Journal Of Medicinal Chemistry - ResearchGate
DNA intercalators Drug discovery Docking Molecular modeling Anticancer agents Cancer chemotherapy cancer therapy, the discovery of new DNA intercalators has been considered a practical approach and a number of intercalators have been recently reported. ... Read Here

Therapy-related AML: A Slip Of The Lip Can Sink A Ship
[1,2]), especially if the prior anti-cancer therapy included drugs such as alkylators, DNA-intercalators, topoisomerase-2-inhibitors, purines and/or ionizing radiation.1 Sometimes specific genes such as AML1, EVI1, NRAS, MLL are mutated in cases of ... View This Document

Publications - Western Sydney University
Publications: Sharon Kemp Current Wheate, N.J., Brodie, C. R., Collins, J. G., Kemp, S. and Aldrich-Wright, J. R. (2007) DNA intercalators in cancer therapy: Organic and inorganic drugs Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils. Journal of ... Read Content

Colorimetric Recognition Of DNA intercalators With Unmodified ...
Colorimetric recognition of DNA intercalators with unmodified gold nanoparticlesw Aiping Xin, Qiupeng Dong, Cen Xiong and Liansheng Ling* widely studied because they play a crucial role in cancer therapy.1,2 Strong binding to DNA and slow dissociation from ... Return Doc

Molecular Mechanisms And Kinetics Between DNA And DNA Binding ...
Molecular Mechanisms and Kinetics between DNA and DNA Binding Ligands cancer therapy. intercalators ethidium bromide, YO-1, and daunomycin as well as the bisintercalator YOYO-1 on l-DNA. Binding of molecules ... Return Document

Mechanism Of Generation Of Therapy Related Leukemia In ...
Both types of agent are cytotoxins widely used in cancer therapy, DNA topoisomerase II, referred to as TOP2, are strong DNA intercalators. In addition to direct TOP2 poisoning and intercalation, ROS stimulated ... Document Viewer

Neutron Capture therapy Of cancer - Wikipedia, The Free ...
Neutron capture therapy of cancer. Boronated DNA metallo-intercalators: Boron-containing nanoparticles: Transferrin–polyethylene glycol (TF–PEG) liposomes: Carboranyl porphrazines: Unnatural amino acids: Boronated cyclic peptides: ... Read Article

Organometallic Compounds in Cancer Therapy: Past Lessons And ...
Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions Pedro Martins , ferrocene with DNA intercalators or ferrocenyl derivatives as inhibitors of topoisomerase being able to target DNA in cancer cells leading to molecular damage and ultimately the death of ... Doc Viewer

Biological Properties Of 4-methyl-2,7-diamino-5,10-diphenyl-4 ...
Are important drugs for cancer therapy today. Some of the DNA intercalators such as doxorubicin, epirubicin [7–9]. Several antibiotics are DNA intercalators and are recognized as the new, prom-ising class of DNA antitumor agents [10]. Numerous intercalating compounds are currently in ... Access Full Source

Targeted Therapy - Fundamentals
Targeted Therapy - Fundamentals Dr Sreejith Nair, Dept of Medical Oncology, DNA intercalators 5. Topoisomerase inh Problems 1. Toxicity 2. Non Specific 3. Low TI 4. Resistance 5. 5 - Cancer Vaccines Source Type Malignancy ... Retrieve Content

New Therapeutic Targets in Cancer - University Of Cambridge
New Therapeutic Targets in Cancer Duncan Jodrell, • DNA intercalators • DNA topoisomerase inhibitors . Predictive biomarkers in cancer therapy Oestrogen receptor status and hormonal therapy for patients with breast cancer ... Access Full Source

DNA-intercalators Causing Rapid Re-expression Of Methylated ...
DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells M. Zulfiquer Hossain 1, Megan A. Healey, Calvin Lee, Weijie Poh1, Sashidhar R. attractive targets for cancer therapy. Reprogramming ... View Doc

The Synergistic Effects Of DNA-Targeted Chemotherapeutics And ...
Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatmenta cancer therapy. Histone deacetylases (HDAC) seem to be most important [2] DNA Intercalators and Inhibitors of Topoisomerase II 4.1.1.1. ... Return Doc

Chapter 11 The Auger Effect In Molecular Targeting Therapy
Emission is described and the major attempts to use such emitters in cancer therapy are discussed. Focus is on the need for nuclear localization of the Auger-electron guide DNA-intercalators to their target in order to achieve tumour cell specificity. ... Retrieve Here

Considerations Concerning Design And Mechanism Of Action Of A ...
Considerations concerning design and mechanism of action of a new class of anticancer dual DNA intercalators Mihaela Ca˘ta˘lina C. Lucaa, Vasile V. Turab, Ionel I. Mangalagiuc,⇑ ... View Full Source